<em>In vitro</em> Anti-inflammatory, Anti-oxidant and Cytogenotoxicity of <em>Axinella</em> sp., a Marine Sponge Extract

Exploring the oceans for bioactive compounds is an incessant human desire. The present study investigates selected bioactivities; anti-inflammatory, anti-oxidant, cytotoxic, and genotoxic potential of Axinella sp. marine sponge crude extract (SCE). Sponge identification was based on morphology skeletal analysis. SCE prepared by methanol/dichloromethane extraction tested zoo-chemicals, anti-inflammatory properties protein denaturation, heat hypertonicity-induced bovine erythrocyte membrane stability assays. Radical scavenging activity against 2,2-diphenyl-1-picryl-hydrazil (DPPH), 2,2′-Azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS), nitric oxide (NO), peroxide radicals. IC50 calculated each assay. Cytotoxicity genotoxicity were Artemia salina Allium cepa models, respectively. LC50 mitotic index (MI) where appropriate, while chromosomal aberrations recorded in A. results indicated presence alkaloids, terpenoids, unsaturated sterols, flavonoids, saponins SCE. Potent inhibitory activities egg albumin denaturation reported (IC50=39.55±3.21 μg/ml). Heat hypertonicity induced as IC50=44.64±0.56 μg/ml IC50=35.7±.0.26 μg/ml, In comparison to reference drugs, resulting strong NO (IC50=50.63±2.85 μg/ml) more or less similar DPPH (IC50=42.49±0.85 However, potency ABTS radical low (IC50=42.49±0.74 IC50=323.52±3.71 respectively). toxic nauplii (LC50=106.81 root cells (LC50=114.63 with a 7.2% potent effects proposes its feasibility drug lead, followed further comprehensive research.